Endothelial Cell Dysfunction Can Be Assessed by 3 Methods

Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats

Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (72 μg/kg, ...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

ارزیابی فعالیت آنزیم نیتریک اکسید سنتتاز در سلول‌های آندوتلیال آئورت موش‌های صحرایی سالم و دیابتی به روش هیستوشیمیایی NADPH دیافورزیز

Impaired endothelium-dependent relaxation of blood vessels is a common feature in diabetes but the exact underlying mechanisms have not yet been clarified. In the present study, endothelium-dependent vasorelaxation of aortic rings were evaluated in vitro in streptozocin-induced diabetic and age-matched control rats. Moreover, NO synthase activity of aortic endothelial cells was asse...

The Effect of Combining Resistance Training and Endothelial Progenitor Cell Injection on the Expression of Angiogenic Factors In Diabetic Male Rats Induced By Stz

Background: Angiogenesis disorders are known mechanisms of diabetes. With the aim of reducing angiogenesis disorders, resistance training and its combination with endothelial progenitor cell injection are new strategies. Therefore, the present study was performed to determine the effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in ...

Colony Forming Unit Endothelial Cells Do not Exhibit Telomerase Alternative Splicing Variants and Activity

Introduction: Endothelial progenitor colony forming unit-endothelial cells (CFU-EC) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. Further studies revealed that they are monocytes regulating vasculogenesis. The main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. This study was unde...

Simultaneous Effect of Resistance Training and Endothelial Progenitor Cell Injection on the Expression of Vegf Angiogenic Factor and Its Relationship with Insulin Resistance in Diabetic Male Rats Induced By Stz

Background: Exercise and the simultaneous use of progenitor cells is a new strategy aimed for reducing diabetic disorders. One of the known mechanisms is angiogenic disorders caused by diabetes. Therefore, the present study was performed to determine the simultaneous effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal ...